Reciprocal antagonism of PIN1-APC/CCDH1 governs mitotic protein stability and cell cycle entry
Abstract Induced oncoproteins degradation provides an attractive anti-cancer modality.Activation of anaphase-promoting complex (APC/CCDH1) prevents cell-cycle entry by targeting crucial mitotic proteins for degradation.Phosphorylation of its co-activator CDH1 modulates the E3 ligase activity, but little is known about its regulation bostik roll-cot